Communication in Airway Cells TLR2 Regulates Gap Junction Intercellular
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Irsogladine maleate regulates gingival epithelial barrier function and intercellular communication in gingival epithelial cells
Epithelial cells function as a mechanical barrier against invasion by pathogenic organisms and promote intercellular communication through cell-cell junction complexes. Therefore, the permeability and homeostasis of the gingival epithelial cell layer indicates a defensive capability against invasion by periodontal pathogens. Irsogladine maleate is a medication for gastric ulcer, and is also kno...
متن کاملConnexins and intercellular communication in arterial growth and remodeling
Gap junction functionality and intercellular exchange of chemical messengers and other biologically important cellular signals makes communication between adjacent cells possible and is essential for multicellular living systems. This intercellular communication is carried out through gap junction channels that are comprised of multimeric connexin (Cx) proteins and that provide physical linkage...
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Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signalling. The functional integrity of the endothelium is under the influence of a network of gap junction intercellular communication channels composed of Cxs (connexins) that also for...
متن کاملThe Canonical WNT2 Pathway and FSH Interact to Regulate Gap Junction Assembly in Mouse Granulosa Cells1 Running title: WNT pathway regulates follicle gap junctions
WNTs are extracellular signaling molecules that exert their actions through receptors of the frizzled (FZD) family. Previous work indicated that WNT2 regulates cell proliferation in mouse granulosa cells acting through CTNNB1 (beta-catenin), a key component in canonical WNT signaling. In other cells, WNT signaling has been shown to regulate expression of connexin43 (CX43), a gap junction protei...
متن کاملThe canonical WNT2 pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells.
WNTs are extracellular signaling molecules that exert their actions through receptors of the frizzled (FZD) family. Previous work indicated that WNT2 regulates cell proliferation in mouse granulosa cells acting through CTNNB1 (beta-catenin), a key component in canonical WNT signaling. In other cells, WNT signaling has been shown to regulate expression of connexin43 (CX43), a gap junction protei...
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